Vector Laboratories has launched the Glysite™ Explorer in situ PLA Glycan Detection Kit, a groundbreaking tool developed in collaboration with Navinci. This innovative kit is designed to significantly advance functional proteomics research by allowing scientists to spatially detect glycans in close proximity to specific proteins within tissue samples.

The Glysite™ Explorer kit stands out as the first commercially available product of its kind that specifically addresses protein glycosylation in a spatial context. It achieves this by combining Vector's meticulously validated lectins (molecules that bind to carbohydrates) with Navinci's proprietary in situ Proximity Ligation Assay (isPLA) technology. This powerful combination allows researchers to go beyond simply identifying proteins and delve into their glycosylation state, which is crucial for understanding protein function and cellular processes.

This new kit provides a streamlined, easy-to-use, and reproducible approach for investigating protein glycosylation in various sample types, including FFPE tissues, FFPE cell pellets, and fixed cells. By integrating this new "multiomic" dimension into data analysis, scientists can gain deeper insights into the role of protein glycosylation in disease biology, biomarker discovery, and translational studies. A significant advantage is that the kit is designed to be compatible with existing laboratory equipment and workflows, making it highly accessible for researchers looking to generate new data without needing extensive new infrastructure.

This collaboration between Vector Laboratories, a leader in proteomic and glycomic solutions, and Navinci, an expert in in situ PLA technology, aims to make the complex study of protein glycosylation more accessible and provide invaluable insights into how these modifications influence protein function and disease.