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10x Genomics Launches Xenium Protein, Advancing Spatial Biology by Enabling Same-Cell RNA and Protein Analysis
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A new and significant advancement in the field of multiomic analysis has been introduced by 10x Genomics a company specializing in single cell and spatial biology, in the form of its Xenium Protein product. This new offering allows researchers to simultaneously detect both RNA and protein in the same cell and on the same tissue section during a single, automated run. By integrating these two crucial types of data, the Xenium Protein platform eliminates the need for separate workflows and complex data integration, which often introduces uncertainty and slows down discovery. This streamlined process is designed to help scientists gain deeper insights into cell function and disease biology more efficiently.

The Xenium Protein launch expands the capabilities of the company's existing Xenium Spatial platform.

It includes pre-packaged protein subpanels that can be used alongside existing RNA panels, allowing for a truly comprehensive analysis. These initial subpanels target dozens of proteins that play key roles in various biological processes, including cell growth, signaling, and immune response. This makes the platform particularly valuable for studying complex diseases like cancer and those related to immunology.

By capturing both RNA and protein data in one experiment, the new tool simplifies the research process from experimental design to obtaining results, which in turn helps accelerate the pace of valuable discoveries.

Early feedback from researchers, including Dr. Julien Tessier of Sanofi, highlights the benefits of this integrated approach. Dr. Tessier noted that the ability to analyze RNA and protein within a single Xenium workflow provides a more complete view of tissue architecture and cell-cell interactions. This integrated multiomics approach bypasses the challenges of data co-registration, delivering critical insights into biomarker and target expression that RNA analysis alone may not capture. With the global availability of Xenium Protein, 10x Genomics continues to provide integrated research solutions that are used by academic and biopharmaceutical companies to accelerate biological understanding and improve human health.

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