Oncotelic Therapeutics Inc. (formerly known as Mateon Therapeutics, Inc.), initially formed as OXiGENE, Inc. in New York in 1988, reincorporated in Delaware in 1992, and underwent name changes in 2016 and 2020. Oncotelic aims to leverage its expertise in oncology drug development to enhance treatment outcomes, particularly for rare pediatric cancers. The company has rare pediatric designations for conditions such as Diffuse Intrinsic Pontine Glioma (through OT-101), melanoma (through CA4P), and Acute Myeloid Leukemia (through OXi 4503). Oncotelic acquired PointR Data Inc. in November 2019 to build an AI-driven biotech company and, in the fourth quarter of 2021, acquired AL-101 for intranasal apomorphine delivery. The company intends to develop AL-101 to treat Parkinson's Disease, erectile dysfunction, female sexual disorder, and hypoactive sexual desire disorder.