Infinity Pharmaceuticals, Inc., is a clinical-stage biotechnology company developing eganelisib (IPI-549), a potential first-in-class, oral, immuno-oncology macrophage reprogramming therapeutic designed to address a fundamental biologic mechanism of immune suppression in cancer. MARIO-3 is a clinical study evaluating eganelisib in combination with atezolizumab and nab-paclitaxel in front-line triple negative breast cancer (TNBC) and in combination with atezolizumab and bevacizumab in front-line renal cell carcinoma (RCC). MARIO-275 is a randomized, controlled combination study of eganelisib combined with nivolumab in I/O naïve urothelial cancer.