Contineum Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel, oral small molecule therapies for NI&I indications with high unmet need. Contineum is focused on targeting biological pathways associated with specific clinical impairments, that the Company believes, once modulated, can demonstrably impact the course of disease. The Company has a pipeline of internally-developed programs to address multiple NI&I disorders, including PIPE-791, an LPA1 receptor antagonist, in Phase 1 for idiopathic pulmonary fibrosis and progressive multiple sclerosis, and PIPE-307, a potentially first-in-class selective inhibitor of the M1 receptor in Phase 2 for relapse-remitting multiple sclerosis and with a Phase 2 for depression planned to initiate in mid-2024. Contineum is developing PIPE-307 in collaboration with Johnson & Johnson Innovative Medicines. In addition, Contineum is advancing discovery efforts targeting other NI&I indications where the Company’s internally-discovered molecules and approach may have therapeutic potential.