Arxx Therapeutics is a Scandinavian biotechnology company founded by scientists and drug developers dedicated to help the large number of patients whose lives are impacted by fibrotic disease. Arxx is leveraging more than 30 years of research by its scientific co-founders uncovering the pathobiology of S100A4; a Damage Associated Molecular Pattern protein upregulated upon stress or injury allowing cells to sense and react to danger. In chronically diseased tissue, S100A4 is inappropriately activated which leads to persistent inflammation and non-resolving tissue fibrosis. The company’s lead candidate, AX-202, is a fully humanized, high-affinity monoclonal antibody neutralizing the bioactivity of S100A4. AX-202 confers targeted, upstream and disease-specific modulation of the self-sustaining feedback loop driving persistent fibrogenesis. An ongoing phase 1 trial is designed to establish safety and tolerability of AX-202 in healthy volunteers and patients with psoriasis and is being conducted at the Medicines Evaluation Unit in Manchester, UK in cooperation with CRO-Solutions.