Houston-based March Biosciences, launched from the Center for Cell and Gene Therapy (Baylor Medical School, Houston Methodist Hospital, Texas Children's Hospital), is dedicated to addressing challenging cancers unresponsive to current immunotherapies. Its lead asset, MB-105, is a CD5-targeted CAR-T cell therapy currently in Phase I trials in patients with refractory T-cell lymphoma and leukemia, with promising signals of efficacy and safety to date. A Phase 2 trial is expected to begin next year. The company was incubated by the CPRIT-supported Accelerator for Cancer Therapeutics, with a seed funding round co-led by the Texas Medical Center Venture Fund (TMC Ventures) and Portal Innovations.